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Description
Purified anti-CX3CL1 (Fractalkine). CX3CL1 is the only member of the CX3C chemokine family that is constitutively expressed in endothelial and epithelial cells, lymphocytes, neurons and microglial osteoblasts. CX3CL1 exists in two forms: as a membrane-anchored form of approximately 100 kD or as a shed 80-95 kD glycoprotein. The chemokine domain is roughly 8 kD, but it migrates at about 13 kD. Its membrane bound form promotes the firm adhesion of rolling leucocytes onto the vessel wall, while its soluble form serves as a potent chemoattractant for CX3CR1-expressing cells such as NK cells, CD14+ monocytes, cytotoxic effector T cells, B cells, neurons, microglia, smooth muscle cells, and tumor cells. The CX3CL1/CX3CR1 axis plays an important role in the pathogenesis of several inflammatory diseases such as allergic pathologies, rheumatoid arthritis, atherosclerosis and tumorigenesis.
Immunogen
Recombinant human CX3CL1
Other Names
Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1), ABCD-3, Fractalkine, Neurotactin (NTT, NTN), Small Inducible Cytokine Subfamily D (Cys-X3-Cys), Member 1 (SCYD1), CXC3C