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Description
The dendritic cell lysosomal?associated membrane protein (DC?LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa mw in the mouse and 90 kDa mw in humans (due to extensive glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine?based lysosomal targeting motif in its cytoplasmic tail Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi?lamellar bodies, known as MIIC (MHC class II compartments) in human mature DC and as pulmonary surfactant?containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface. (de Saint-Vis B et al., 1998 Immunity , 9: 325-336)
Immunogen
n/a
Other Names
Dendritic cell lysosomal?associated membrane protein