A multimodal serotonergic agent; inhibits 5-HT reuptake (Ki = 1.6 nM); binds to the 5-HT1A, 5-HT1B, 5-HT3A, and 5-HT7 receptors (Kis = 15, 33, 3.7, and 19 nM, respectively); binds to the β1-adrenergic receptor (Ki = 46 nM); acts as an antagonist at 5-HT3A and 5-HT7, a partial agonist at 5-HT1B, and a full agonist at 5-HT1A receptors; selective for SERT over the dopamine and norepinephrine transporters (IC50s = 5.3, 890, and 140 nM, respectively); increases 5-HT levels in vivo in rat brain and decreases occupancy at SERT when administered at a dose of 5 or 10 mg/kg per day; has antidepressant-like and anxiolytic-like effects in mice at 5 mg/kg but not 10 mg/kg