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Description
Rabbit IgG polyclonal Picoband? antibody for TPR detection. Tested with WB, IHC-P, IHC-F, ICC/IF, FCM in Human;Mouse;Rat. No cross reactivity with other proteins. The tetratricopeptide repeat (TPR) is a structural motif. This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias.
Immunogen
A synthetic peptide corresponding to a sequence of human TPR (MLQAEKKLLEEDVKRWKARNQHLVSQQKD).