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Description
Function: Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival. Tissue specificity: Widely expressed in the brain and spinal cord neurons. Subcellular location: Membrane, Multi-pass membrane proteinSynonyms: NALCN, Sodium leak channel non-selective protein, Voltage gated channel-like protein 1
Immunogen
A synthetic peptide from internal region of human VGCNL1 (Voltage gated channel like protein 1) conjugated to an immunogenic carrier protein was used as the antigen.