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Description
Rabbit IgG polyclonal Picoband? antibody for Annexin A3(ANXA3) detection. Tested with WB, IHC-P, IHC-F, ICC in Human;Mouse;Rat. No cross reactivity with other proteins. Annexin A3 is a protein that in humans is encoded by the Annexin A3 gene. The Annexin A3 gene contains 13 exons and spans 58 kb of genomic DNA. The Annexin A3 gene is mapped to 4q21. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human Annexin A3 (153-184aa RKALLTLADGRRDESLKVDEHLAKQDAQILYK), different from the related mouse sequence by one amino acid, and from the related rat sequence by three amino acids.