Interleukin 1 Family, Member 6 (IL1F6) (AA 1-158) protein
Description
Human Interleukin-36alpha (IL-36alpha) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36alpha is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36alpha is the only IL-1 family member found to be expressed on T-cells. IL-36alpha and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-36alpha inhibits PPARgamma expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36alpha, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFkappaB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36alpha may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.Alternative Names: Interleukin-36 Alpha, FIL1 Epsilon, Interleukin-1 Epsilon, IL-1 Epsilon, Interleukin-1 Family Member 6, IL-1F6, IL36A, FIL1E, IL1E, IL1F6