A selective and highly potent inhibitor of DLK; also inhibits phosphorylated JNK (IC50 = 30 nM); selective over other MAP kinases, JNKs, and MLKs; protects primary neurons in an in vitro axon degeneration assay (IC50 = 107 nM); decreases p-c-Jun expression in a mouse MPTP model of Parkinson's disease,