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Description
Rabbit Anti-APP (Phosphorylated S730) Polyclonal Antibody (PTM-CBPAB-0217YC). Provided herein is a Rabbit polyclonal antibody against Amyloid Beta Precursor Protein. The antibody can be used for immunoassay techniques, such as IF, IHC-P. APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations
Immunogen
KLH conjugated phosphopeptide, human APP770 around Ser730