A selective CB2 receptor inverse agonist (Kds = 25 and 2,370, 1.55 and 1,060, and 0.38 and 1,050 nM for human, mouse, and rat CB2 and CB1 receptors, respectively); increases forskolin-stimulated cAMP production in CHO cells expressing human and mouse CB2 in a dose-dependent manner; inhibits carrageenin-induced edema in mouse paws (ED50 = 0.05 mg/kg); inhibits spontaneous scratching in a mouse model of chronic dermatitis