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Description
Rabbit IgG polyclonal antibody for D(2) dopamine receptor(DRD2) detection. Tested with WB, IHC-P, IHC-F in Human;Mouse;Rat. No cross reactivity with other proteins. Dopamine receptor D2, also known as D2R or D2DR is a protein that in humans is encoded by the DRD2 gene. DRD2 gene is mapped to 11q23.2. This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Dopamine D2 Receptor(360-375aa RRKLSQQKEKKATQML), identical to the related rat and mouse sequences.