Recombinant Human Podocalyxin protein (PODXL), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 46.2kDa. Partial: 32-458aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma mbrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
GCTM-2 antigen; Gp200Podocalyxin-like protein 1; PC; PCLP-1