Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) protein (His tag)
Description
SOCS-3 is an SH2-containing protein predominantly expressed in T-helper type 2 cells, that binds to the activation loop of Janus kinases, inhibiting the kinase activity and thereby suppressing cytokine signaling. SOCS-3 therapy may be useful in the treatment of cancer. SOCS-3 has an important role in regulating the onset and maintenance of TH2-mediated allergic immune disease and is a new therapeutic target for antiallergic drugs.