Recombinant Human Frizzled-10-Fc Chimera (carrier-free)
Description
Frizzled-10 (FZD10), also known as CD350, is a G-protein coupled receptor with seven transmembrane domains. It is one of ten Frizzled family of Wnt receptors whose extracellular cysteine rich domain (CRD) binds Wnt proteins. Frizzled receptors are ubiquitously and dynamically expressed in most cells. Frizzled receptors associate with low density lipoprotein receptor-related proteins (LRP6/LRP6) to transduce Wnt signals through the activation of disheveled proteins, inhibition of GSK-3 kinase, and stabilization of beta-catenin which accumulates in the nucleus to promote Wnt-mediated gene transcriptions. Another signaling pathway involving PKC and calcium fluxes has been described, but it is not yet established as a distinct pathway independent of canonical pathway. Frizzled-10 is highly expressed in the placenta, fetal kidney, lung and brain. In the adult brain, it is expressed in the cerebellum, cerebral cortex, medulla and spinal cord. Weak expression is also detected in adult heart, lung, skeletal muscle, pancreas, spleen and prostate. Frizzled-10 is also up-regulated in several cancers and transformed cell lines. It may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and differentiation.