IL-17A, a homodimeric cytokine of about 32 kDa, is largely produced by activated memory T lymphocytes, but stimulates innate immunity and host defense. IL-17A and IL-17F both mobilize neutrophils partly through granulopoeisis and CXC chemokine induction, as well as increased survival locally. IL-17A and IL-17F production by T lymphocytes is regulated by IL-23 independent of T cell receptor activation. The Th1 and Th2 cell classification has until recently provided the framework for understanding CD4+ T cell biology and the interplay between innate and adaptive immunity. The Th17 lineage produces interleukin 17, which is highly proinflammatory and induces severe autoimmunity. Increased levels of IL-17 have been associated with several conditions, including airway inflammation, rheumatoid arthritis, intraperitoneal abscesses and adhesions, inflammatory bowel disease, allograft rejection, psoriasis, cancer and multiple sclerosis. Sample Types: cell culture, citrate plasma, EDTA plasma, heparin plasma, serum. Sample Size: 50 μL. Range: 1.6 - 100 pg/mL. Sensitivity: 1.0 pg/mL. Time: 3hr 30min
Size
96 wells
Concentration
n/a
Applications
Immunoassays. Research Use Only. Not for Use in Diagnostic Procedures.