Immunohistochemistry (Paraffin): 5 μg/mL, Western Blot: 1-3 μg/mL
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Description
MEKK2 Polyclonal Antibody. MEKK2 is a serine/threonine protein kinase, belonging to the MAP (mitogen-activated protein) kinase family. It plays an important role in activation of MAPK and preferentially activates other kinases involved in the MAP kinase signaling pathway. MEKK2 is known to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. It regulates T-cell function, controls cytokine gene expression in mast cells, mediates epidermal growth factor (EGF) receptor and fibroblast growth factor-2 (FGF-2) receptor signals,and plays a role in rheumatoid arthritis. It is also involved in LPS-TLR4 signaling, due to its phosphorylation by TLR4 ligand, LPS.