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Description
BAG4 Monoclonal Antibody (2G9). The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein
Immunogen
n/a
Other Names
BAG-4, SODD; BAG family molecular chaperone regulator 4; BAG-family molecular chaperone regulator-4; bcl-2-associated athanogene 4; silencer of death domains