Purified (~70-90%). MATK belongs to tyrosine protein kinase family, CSK subfamily. It inactivates Src family kinase activity by specifically phosphorylating their C-terminal regulatory tyrosine residue and may plays a significant role in the signal transduction of hematopoietic cells. MATK binds to the phosphorylated Tyr568/570 sites on c-KIT to which FYN binds and leads to the down-regulation of FYN. MATK has been shown to be involved in signaling in some cases of breast cancer. Source: Recombinant protein corresponding to human MATK, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~83kD Specific Activity: 11nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL)