Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high μM to mM concentrations.{9837} It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism.
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
DNA binding anti-oncogenic apoptosis cancer p53 re-activator reactivator induces apoptotic re-activation reactivation antioncogenic cancers 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one