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Description
ABI1 Polyclonal Antibody. May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level .
Immunogen
n/a
Other Names
ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1, Abelson interactor 1, Abl-interactor protein 1 long, abl interactor 1, abl-binding protein 4, eps8 SH3 domain-binding protein, interactor protein AblBP4, nap1 binding protein, spectrin SH3 domain-binding protein 1