An HSP90 inhibitor (IC50 = 10 nM in a fluorescence polarization assay); decreases HER2 protein expression (IC50 = 110 nM) in BT474 breast cancer cells; inhibits the growth of a 16 cancer cell line panel (IC50s = 13-362 nM); reduces tumor growth by 74% in an A2780 mouse xenograft model at a dose of 60 mg/kg, i.v., per day for ten days; completely eradicates MOLM-13 acute myeloid leukemia tumors in a mouse xenograft model
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
NMSE-973 NMSE973 HER-2 MOLM13 hsp-90 BT-474 AML human epidermal growth factor extracellular?signal?regulated kinase