Immunohistochemistry: 1:300 - 1:2000, Western Blot: 1:300-1:2000
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Description
gamma-ENaC Polyclonal Antibody. Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. Apical cell membrane; Multi-pass membrane protein. Phosphorylated on serine and threonine residues. Defects in SCNN1G are a cause of Liddle syndrome. It is an autosomal dominant disorder characterized by