Immunocytochemistry: 1:100, Immunofluorescence: Assay-Dependent, Immunohistochemistry: 1:200, Western Blot: 1:200
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Description
P2X7 (extracellular) Polyclonal Antibody. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.