Immunohistochemistry: 3.75 μg/mL, peptide-ELISA: 1:4000, Western Blot: 1-3 μg/mL
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Description
PXR Polyclonal Antibody. This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
Immunogen
n/a
Other Names
PXR; NR1I2; nuclear receptor subfamily 1, group I, member 2; BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; SAR; SXR; orphan nuclear receptor; pregnane X receptor; steroid and xenobiotic receptor