A selective inhibitor of CHOKα (IC50s = 1 and >50 μM for CHOKα and β, respectively); induces apoptosis via CHOP signaling and ER stress in MDA-MB-231, MCF-7, SW620, and H460 cancer cells; inhibits the growth of HT-29 colon cancer cells in vitro (IC50 = 1.15 μM) and in vivo in a mouse xenograft model (ED50 = 7.5 mg/kg) ,