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Description
CDKN1B / p27 Kip1 Antibody LS-C42562. Detects p27, a member of the Kip/Cip family of proteins which is also known as p27kip1. p27 is a cyclin dependent kinase inhibitor (CKI) which controls G1/S phase transition in the cell cycle. p27 prevents cell cycle progression by inhibiting the activity of cyclin E-Cdk2 and cyclin D-Cdk4/6, thus preventing E2F activation and S phase progression. Low p27 levels and/or cytosolic mis-localization have been associated with the development of lung, breast, colon, esophagus, and prostate tumors. Does not react with: Mouse