Purity >97%. Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPAR alpha demonstrates a particular role in fatty acid oxidation whereas PPAR gamma is known to be involved in adipocyte differentiation and lipid storage. LT175 is a dual PPAR alpha / gamma ligand that displays partial agonism toward PPAR gamma (EC50s = 0.22, 0.26, and 0.48 μM for hPPAR alpha, mPPAR alpha, and hPPAR gamma, respectively). It exhibits low adipogenic activity in vitro and improves glucose homeostasis in diet-induced insulin resistant mice. LT175 was shown to disrupt the recruitment of coregulators, cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1, to PPAR gamma .