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Description
ACAP2 Polyclonal Antibody. ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by AT
Immunogen
n/a
Other Names
ACAP2; CENTB2; centaurin, beta 2; CNT-B2; KIAA0041; centaurin beta2; Arf GAP with coiled coil, ANK repeat and PH domains 2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2