Purity >98%. Lonidamine, originally identified as a potent antispermatogenic agent, inhibits glycolysis though the inactivation of mitochondria-bound hexokinase. It can decrease oxygen consumption as well as aerobic and anaerobic glycolysis in Ehrlich ascites tumor cells with IC50 values of 90 and 45 μM, respectively. A role for lonidamine as a therapeutic for mitochondrial dysfunction has been explored in various disorders, including cancer, neurodegenerative and neuromuscular diseases, obesity, and diabetes.
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Other Names
1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid, AF 1890, DICA, Diclondazolic Acid