A primary amide analog of (+)-JQ1 which has shown superior bioavailability with oral or i.p. administration; inhibits BRD4 binding and action in vitro or in cells; arrests the growth of leukemia T cells in vitro (EC50 = 91 nM) and rapidly suppresses leukemia burden in mice
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
202591-23-9 inhibitors inhibits inhibitions cancers chromatin research epigenetics genes regulation histones modifications CPIs CPI203 203 arrests leukemic T cells T-cells Tcells in vitro analog amide JQ1 JQ-1 JQs 1 BRD4 BRD-4 BRDs 4 binding binds binders