A neuropeptide hormone; binds to type 1 and 2 CRF receptors as well as CRF-BP (Kis = 0.41, 1.8, 1.5, and 0.22 nM for human CRF1, rat CRF2α, mouse CRF2β, and human CRF-BP, respectively); induces cAMP production in CHO cells expressing human CRF1, rat CRF2α, and mouse CRF2β receptors (EC50s = 0.22, 0.32, and 0.13 nM, respectively); inhibits migration and proliferation of human VSMCs and reduces LDL-induced foam cell formation in vitro; slows development of aortic atherosclerotic lesions in Apoe-/- mice; decreases food intake in food-deprived and non-deprived rats as well as water intake in water-deprived rats in a dose-dependent manner
Size
500 μg
Concentration
n/a
Applications
n/a
Other Names
176591-49-4 nondeprived CRF-1 2α 2β CRFBP low density lipoprotein