產(chǎn)品名稱(chēng) NOX Inhibitor VII, Thr101 from UNITED STATES BIOLOGICAL
    產(chǎn)品貨號(hào) 217599
    產(chǎn)品價(jià)格 現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703
    產(chǎn)品規(guī)格 25mg
    產(chǎn)品品牌 UNITED STATES BIOLOGICAL
    產(chǎn)品概述
    產(chǎn)品詳情
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    Product NameNOX Inhibitor VII, Thr101
    DescriptionPurity ~98% (HPLC). A cell-permeable, selenium-to-sulfur substituted Ebselen derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phox c-terminal PRD (proline-rich domain) and p47phoxbis-SH3 interaction. Although less potent than Ebselen in cell-free p22phox PRD-p47phoxbis-SH3 binding (IC50 = 4 vs. 0.3uM) and NOX2 activity (IC50 = 4 vs. 0.6uM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50 /Ebselen IC50 = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7uM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity. Primary Target: Blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction Solubility: DMSO (50mg/ml) Atmophere: Inert gas
    Size25mg
    Concentrationn/a
    Applicationsn/a
    Other NamesNOX Inhibitor VII, Thr101 (NADPH Oxidase Inhibitor VII, 6-Fluoro-2-o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one)
    Gene, Accession, CAS #n/a
    Catalog #217599
    Price
    Order / More InfoNOX Inhibitor VII, Thr101 from UNITED STATES BIOLOGICAL
    Product Specific Referencesn/a
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