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Description
CT-CD4 monolconal antibody (mAb) recognizes mouse CD4 (L3T4) which is expressed on the majority of thymocytes and on the MHC class II re- stricted subset of mature T cells including Th cells 1,2 . Mouse CD4 has also been reported to be present on multipotential hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic precursors 2,3 . As a coreceptor in the TCR complex, CD4 is involved in T cell activation through interaction with MHC class II on APC's and in signal transduction via protein tyrosine kinase lck This antibody is suitable for use in flow cytometry and is reported to work in immunohistochemistry on acetone fixed frozen sections.