A small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with the ligase binding and activating apoptosis; inhibits cancer cell growth in vitro (IC50s = 8-120 μM) and in mouse models when co-administered with double-strand break-inducing therapeutic compounds
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
1533426-89-9 1533426-90-2 NHEJ DNA ligase IV inhibitor nonhomologous end-joining apoptosis cancer DNA damage repair biochemical inhibit SCR-7 non-homologous endjoining 14892-97-8 pyrazine