Purity >98%. BRD4770 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 μM). Through its effects on EHMT2, BRD4770 induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis. It also blocks both anchorage-dependent and -independent proliferation of PANC-1 cells.
Size
n/a
Concentration
n/a
Applications
n/a
Other Names
2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid, methyl ester, HMTase Inhibitor VI