22-355aa; Full Length. MW: 53.44kD. Purity >90% as determined by SDS-PAGE. Ligand for mbers of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.Roelink H., Wagenaar E., Lopes da Silva S., Nusse R.Proc. Natl. Acad. Sci. U.S.A. 87:4519-4523(1990) The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.Eur. J. Biochem. 267:4300-4311(2000) Reciprocal regulation of Wnt and Gpr177/m