Recombinant Human Dehydrodolichyl diphosphate synthase (DHDDS)
Description
Purity > 90% as determined by SDS-PAGE. MW: 65.7kDa. Full Length: 1-333aa. N-terminal GST-tagged. Homo sapiens (Human). With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.