Purity ≥99% (HPLC, TLC). Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells. Ascomycin (also known as Immunomycin, FR 900520, and FK-520) is an analog of tacrolimus (FK-506) with immunosuppressive, neurotrophic and antifungal activities. Ascomycin can be used to prevent rejection after an organ transplant, and to treat autoimmune diseases and skin diseases. Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells. Paul, C., et al. Ascomycins: promising agents for the treatment of inflammatory skin diseases. Expert Opin. Investig. Drugs. 9: 69-77 (2000). Mollison, K.W., et al. A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases. J. Invest. Dermatol. 112: 729-738 (1999). Antimalarial effects of ascomycin appear to be independent of its immunosuppr
Size
25mg, 50mg, 100mg
Concentration
n/a
Applications
n/a
Other Names
Immunomycin; FK-520; FR-520; NSC-106410; FR 900520; L 683590; Changchuanmycin