Endothelin 2 is a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. The human endothelins represent a gene family comprised of endothelin-1, endothelin-2, and endothelin-3 . Based on the deduced amino acid