Purity ~90% (SDS-PAGE). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Source: Recombinant protein corresponding to aa1-347 from human HDAC11, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~66.2kD AA