Purity ~80% (SDS-PAGE). HDAC8, also known as histone deacetylase 8, belongs to class 1 of the histone deacetylase/acuc/apha family. This protein is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Source: Recombinant protein corresponding to aa1-377 from human HDAC8, fused to His-tag at C-terminal expressed in Sf9 insect cell. Molecular Weight: ~42.6kD (383aa) AA