HDAC8, Recombinant, Human (Active HDAC-8, Recombinat HDAC-8, Human HDAC-8, rh-HDAC-8)
Description
Purity ~90% (SDS-PAGE). Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA). Source: Recombinant corresponding to human HDAC8 expressed in insect cells. Molecular Weight: ~44kD Biological Activity: Activity of rh-HDAC8 was tested using Arg-His-Lys(Ac)-Lys(Ac)-AFC, a fluorogenic, acetylated peptide based on aa379-382 of p53 as a substrate.