CD27 Molecule (CD27) (C-Term), (AA 20-191) protein
Description
Recombinant Human CD27 produced by transfected human cells is a secreted protein with sequence (Ala20-Arg191) of Human CD27 fused with a polyhistidine tag at the C-terminus. CD27 antigen is also known as CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7, T14 and TNFRSF7. In humans, it is encoded by the CD27 gene. CD27 is a single-pass type I membrane protein with 3 TNFR-Cys repeats. It is a member of the TNF-receptor superfamily and is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. It plays a role in survival of activated T-cells and apoptosis through association with SIVA1.