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Description
P53(Ser46) Polyclonal Antibody, Alexa Fluor? 750 Conjugated. ? Target Background: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of
Immunogen
KLH conjugated synthetic phosphopeptide derived from human P53 around the phosphorylation site of Ser46