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Description
FMR1, also known as POF, FMRP, FRAXA. Entrez Protein: NP002015. It is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs.
Immunogen
Purified recombinant fragment of human FMR1 expressed in E. Coli.
Other Names
FMR1; fragile X mental retardation 1; FMRP; FRAXA; MGC87458; Fragile X mental retardation protein 1; POF; POF1; Protein FMR-1