A prodrug form of itaconate; hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages; increases Nrf2 protein levels and expression of Nrf2 target genes and enhances LPS-induced Nrf2 stabilization in mouse macrophages; decreases serum levels of IL-1β and TNF-α, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice at 50 mg/kg