Discs, Large Homolog 1 (Drosophila) (DLG1) (aa 2-50)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human, rat, mouse
Isotype
n/a
Format
serum
Size
100 μL
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
Reviews / Ratings
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Description
Function: Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.Subcellular location: Membrane, Peripheral membrane protein. Basolateral cell membrane. Endoplasmic reticulum membrane. Cell junction ?? synapse ?? postsynaptic cell membrane ?? postsynaptic density. Cell junction ?? synapse. Cell membrane ?? sarcolemma. Note: Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities.Tissue specificity: Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles. Also known as: DLG1, Disks large homolog 1, Synapse-associated protein 97.
Immunogen
A synthetic peptide from aa region 2-50 of human SAP97 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.