A cell-permeable inhibitor of HIF-1-mediated gene transcription which acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the HRE; reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC50 value of 1.2 nM
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
Antibiotic A 654I|NSC 13502|NSC 526417|Quinomycin A|SK 302B