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Description
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. Synonyms: Polyclonal ATP6V1G2 antibody, Anti-ATP6V1G2 antibody, ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 antibody, ATP6G antibody, ATP6G2 antibody, NG38 antibody, VMA10 antibody.
Immunogen
ATP6 V6 2 antibody was raised in rabbit using the middle region of ATP6 6 2 as the immunogen