The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation. Alternative Names: TIFF-3 protein, TIFF 3, Intestinal trefoil factor protein, TIFF-3, Trefoil Factor 3 protein, ITF protein, TIFF-3 protein, TFI protein, TIFF 3 protein, TIFF3